Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/58826
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Predicting the response of CML patients to tyrosine kinase inhibitor therapy |
Author: | White, D. Hughes, T. |
Citation: | Current Hematologic Malignancy Reports, 2009; 4(2):59-65 |
Publisher: | Current Science Inc. |
Issue Date: | 2009 |
ISSN: | 1558-8211 1558-822X |
Statement of Responsibility: | Deborah L. White and Timothy P. Hughes |
Abstract: | Tyrosine kinase inhibitor (TKI) therapy has significantly changed the treatment paradigm for patients with chronic myeloid leukemia (CML). The firs-tgeneration inhibitor, imatinib, has demonstrated remarkable efficacy in most chronic-phase patients. Disease progression remains a significant risk for the first 2 to 3 years of TKI therapy, but the risk falls significantly thereafter. Early recognition of each individual’s risk of progression may facilitate a customized approach to TKI therapy. Using such an approach, drug selection and treatment intensity would be adjusted on the basis of each patient’s disease profile. Currently available prognostic indicators have limited value in the setting of the potent kinase inhibition afforded by TKIs. Furthermore, these indicators provide little guidance regarding optimal drug choice and dose intensity. In the future, assays that directly assess the efficacy of the protein—drug interaction, taking into account factors intrinsic to the patient and the amount of drug freely available in the plasma, are likely to be of greater value. |
Keywords: | Humans Disease Progression Organic Cation Transporter 1 WT1 Proteins Protein Kinase Inhibitors Prognosis Treatment Outcome Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Rights: | Copyright © 2009 by Current Medicine Group LLC |
DOI: | 10.1007/s11899-009-0009-2 |
Published version: | http://dx.doi.org/10.1007/s11899-009-0009-2 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.