Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/59809
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)-deficient mice |
Author: | Milicevic, Z. Milicevic, N. Laan, M. Peterson, P. Kisand, K. Scott, H. Westermann, J. |
Citation: | Immunology and Cell Biology, 2010; 88(1):50-56 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2010 |
ISSN: | 0818-9641 1440-1711 |
Statement of Responsibility: | Živana Milićević, Novica M. Milićević, Martti Laan, Pärt Peterson, Kai Kisand, Hamish S. Scott and Jürgen Westermann |
Abstract: | The significance of the autoimmune regulator (Aire) transcription regulator in establishing central tolerance has recently been elucidated in great detail. Still, the role of Aire in medullary thymic epithelial cell (mTEC) physiology is not fully understood. To shed more light on this issue, we studied the ultrastructure of mTECs in Aire-deficient thymus. We show that all types of mTECs show ultrastructural signs of activation and increased intracellular traffic, which suggests that in the absence of Aire their physiology is impaired. Type 6 ‘large’ mTECs are fully developed in Aire-deficient mice and more frequent than in the normal thymus. The frequency of type 5 ‘undifferentiated’ mTECs is also increased. Collectively, our results suggest that the role of Aire in the physiology of mTECs could be more profound and not restricted only to the presentation of self-tissue-restricted antigens and/or apoptosis of end-stage fully mature cell types. |
Keywords: | thymus medullary epithelial cells ultrastructure Aire mice |
Rights: | © 2010 Australasian Society for Immunology Inc. All rights reserved |
DOI: | 10.1038/icb.2009.55 |
Published version: | http://dx.doi.org/10.1038/icb.2009.55 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.