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https://hdl.handle.net/2440/60458
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Type: | Journal article |
Title: | Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled Type 2 diabetes |
Author: | Ma, J. Stevens, J. Maddox, A. Wishart, J. Jones, K. Clifton, P. Horowitz, M. Rayner, C. |
Citation: | Diabetes Care, 2009; 32(9):1600-1602 |
Publisher: | Amer Diabetes Assoc |
Issue Date: | 2009 |
ISSN: | 0149-5992 1935-5548 |
Statement of Responsibility: | Jing Ma, Julie E. Stevens, Kimberly Cukier, Anne F. Maddox, Judith M. Wishart, Karen L. Jones, Peter M. Clifton, Michael Horowitz, and Christopher K. Rayner |
Abstract: | OBJECTIVE: We evaluated whether a whey preload could slow gastric emptying, stimulate incretin hormones, and attenuate postprandial glycemia in type 2 diabetes. RESEARCH DESIGN AND METHODS: Eight type 2 diabetic patients ingested 350 ml beef soup 30 min before a potato meal; 55 g whey was added to either the soup (whey preload) or potato (whey in meal) or no whey was given. RESULTS: Gastric emptying was slowest after the whey preload (P < 0.0005). The incremental area under the blood glucose curve was less after the whey preload and whey in meal than after no whey (P < 0.005). Plasma glucose-dependent insulinotropic polypeptide, insulin, and cholecystokinin concentrations were higher on both whey days than after no whey, whereas glucagon-like peptide 1 was greatest after the whey preload (P < 0.05). CONCLUSIONS: Whey protein consumed before a carbohydrate meal can stimulate insulin and incretin hormone secretion and slow gastric emptying, leading to marked reduction in postprandial glycemia in type 2 diabetes. |
Keywords: | Humans Diabetes Mellitus, Type 2 Gastrointestinal Hormones Cholecystokinin Insulin Blood Glucose Dietary Proteins Gastric Emptying Middle Aged Female Male Glucagon-Like Peptide 1 |
Rights: | © 2009 by the American Diabetes Association. |
DOI: | 10.2337/dc09-0723 |
Published version: | http://dx.doi.org/10.2337/dc09-0723 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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