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https://hdl.handle.net/2440/60493
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Type: | Journal article |
Title: | Insulin secretion in healthy subjects and patients with Type 2 diabetes - role of the gastrointestinal tract |
Author: | Ma, J. Rayner, C. Jones, K. Horowitz, M. |
Citation: | Best Practice and Research: Clinical Endocrinology and Metabolism, 2009; 23(4):413-424 |
Publisher: | Bailliere Tindall |
Issue Date: | 2009 |
ISSN: | 1521-690X 1532-1908 |
Statement of Responsibility: | Jing Ma, Christopher K. Rayner, Karen L. Jones and Michael Horowitz |
Abstract: | Postprandial glycaemia is now recognised as the major determinant of average glycaemic control in type 2 diabetes, as assessed by glycated haemoglobin. Therefore, an understanding of the factors influencing both the rise in blood glucose and insulin secretion after a meal is fundamental to the development of dietary and pharmacological approaches to optimise glycaemic control. The gastrointestinal tract regulates the rate at which carbohydrate and other nutrients are absorbed and is the source of regulatory peptides that stimulate pancreatic insulin secretion in the setting of elevated blood glucose levels. This article highlights the importance of the gastrointestinal tract in insulin secretion and glucose homeostasis and discusses potential strategies directed at modification of gastrointestinal function in order to improve glycaemic control in the management of diabetes. |
Keywords: | gastric emptying incretin hormones GLP-1 GIP |
Rights: | Copyright © 2009 Elsevier Ltd All rights reserved. |
DOI: | 10.1016/j.beem.2009.03.009 |
Published version: | http://dx.doi.org/10.1016/j.beem.2009.03.009 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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