Adelaide Research & Scholarship
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https://hdl.handle.net/2440/68314
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| Type: | Journal article |
| Title: | An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo |
| Author: | Liu, L. Ghosh, N. Slivka, P. Fiorini, Z. Hutchinson, M. Watkins, L. Yin, H. |
| Citation: | ChemBioChem: a European journal of chemical biology, 2011; 12(12):1827-1831 |
| Publisher: | Wiley-VCH Verlag GMBH |
| Issue Date: | 2011 |
| ISSN: | 1439-4227 1439-7633 |
| Statement of Responsibility: | Liping Liu, Nilanjan Ghosh, Peter F. Slivka, Zeno Fiorini, Mark R. Hutchinson, Linda R. Watkins and Hang Yin |
| Abstract: | A truncated peptide was shown to retain the structure of the TLR4-binding hot-spot region of MD2, disrupting with the TLR4/MD2 interactions. The peptide not only demonstrated strong binding affinity in the fluorescence polarization assay, but also showed high specificity in macrophage cells. Furthermore, MD2-I was able to suppress neuropathic pain in animal models. |
| Keywords: | Neuroglia Cell Line Macrophages Animals Humans Mice Rats Neuralgia Inflammation Nitrobenzenes Azoles Lipopolysaccharides Peptide Fragments Spectrometry, Fluorescence T-Cell Antigen Receptor Specificity Molecular Mimicry Amino Acid Sequence Protein Binding Molecular Sequence Data Toll-Like Receptor 4 Lymphocyte Antigen 96 Molecular Dynamics Simulation Pain Management |
| Rights: | Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| DOI: | 10.1002/cbic.201100211 |
| Grant ID: | http://purl.org/au-research/grants/arc/DP110100297 |
| Published version: | http://dx.doi.org/10.1002/cbic.201100211 |
| Appears in Collections: | Aurora harvest Earth and Environmental Sciences publications Environment Institute publications |
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