Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/69944
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Type: Journal article
Title: Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
Author: Galluzzi, L.
Vitale, I.
Abrams, J.
Alnemri, E.
Baehrecke, E.
Blagosklonny, M.
Dawson, T.
Dawson, V.
El-Deiry, W.
Fulda, S.
Gottlieb, E.
Green, D.
Hengartner, M.
Kepp, O.
Knight, R.
Kumar, S.
Lipton, S.
Lu, X.
Madeo, F.
Malorni, W.
et al.
Citation: Cell Death and Differentiation, 2012; 19(1):107-120
Publisher: Nature Publishing Group
Issue Date: 2012
ISSN: 1350-9047
1476-5403
Statement of
Responsibility: 
L Galluzzi... S Kumar... et al.
Abstract: In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-related terminology, including ‘apoptosis’, ‘necrosis’ and ‘mitotic catastrophe’. In view of the substantial progress in the biochemical and genetic exploration of cell death, time has come to switch from morphological to molecular definitions of cell death modalities. Here we propose a functional classification of cell death subroutines that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic apoptosis, regulated necrosis, autophagic cell death and mitotic catastrophe. Moreover, we discuss the utility of expressions indicating additional cell death modalities. On the basis of the new, revised NCCD classification, cell death subroutines are defined by a series of precise, measurable biochemical features.
Keywords: autophagy; mitochondrial membrane permeabilization; necroptosis; parthanatos; TNFR1; TP53
Rights: © 2012 Macmillan Publishers Limited
RMID: 0020115638
DOI: 10.1038/cdd.2011.96
Appears in Collections:Medicine publications

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