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https://hdl.handle.net/2440/70119
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Type: | Journal article |
Title: | Utility of peripheral blood B cell subsets analysis in common variable immunodeficiency |
Author: | AlKindi, A. Mundy, J. Sullivan, T. Smith, W. Kette, F. Smith, A. Heddle, R. Hissaria, P. |
Citation: | Clinical and Experimental Immunology, 2012; 167(2):275-281 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2012 |
ISSN: | 0009-9104 1365-2249 |
Statement of Responsibility: | M. Al Kindi, J. Mundy, T. Sullivan, W. Smith, F. Kette, A. Smith, R. Heddle and P. Hissaria |
Abstract: | Abnormalities in peripheral blood B cell subsets have been identified in common variable immunodeficiency (CVID) patients and classification systems based upon their numbers have been proposed to predict the clinical features. We analysed B lymphocyte subsets by multi-colour flow cytometry (MFC) in a cohort of well-characterized CVID patients to look at their clinical relevance and validate the published association of different classification criteria (Freiburg, Paris and Euroclass) with clinical manifestations. CVID patients had a reduced proportion of total and switched memory B cells (MBC, swMBC) compared to normal controls (P < 0·0006). Patients classified in Freiburg Ia had a higher prevalence of granulomatous diseases (P = 0·0034). The previously published associations with autoimmune diseases could not be confirmed. The Euroclass classification was not predictive of clinical phenotypes. The absolute numbers of all B cell subsets were reduced in CVID patients compared to controls. There was a significant linear correlation between low absolute total B cells and MBC with granulomatous disease (P < 0·05) and a trend towards lower B cells in patients with autoimmune diseases (P = 0·07). Absolute number of different B cell subsets may be more meaningful than their relative percentages in assessing the risk of granulomatous diseases and possibly autoimmunity. |
Keywords: | antibody deficiency B cell subtypes common variable immunodeficiency flow cytometry memory B cells |
Rights: | © 2012 The Authors. |
DOI: | 10.1111/j.1365-2249.2011.04507.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2249.2011.04507.x |
Appears in Collections: | Aurora harvest 5 Public Health publications |
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