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https://hdl.handle.net/2440/72379
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dc.contributor.author | Carbone, A. | - |
dc.contributor.author | Psaltis, P. | - |
dc.contributor.author | Nelson, A. | - |
dc.contributor.author | Metcalf, R. | - |
dc.contributor.author | Richardson, J. | - |
dc.contributor.author | Weightman, M. | - |
dc.contributor.author | Thomas, A. | - |
dc.contributor.author | Finnie, J. | - |
dc.contributor.author | Young, G. | - |
dc.contributor.author | Worthley, S. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Cardiac Failure, 2012; 18(6):502-511 | - |
dc.identifier.issn | 1071-9164 | - |
dc.identifier.issn | 1532-8414 | - |
dc.identifier.uri | http://hdl.handle.net/2440/72379 | - |
dc.description.abstract | BACKGROUND: Cumulative dose-dependent nonischemic cardiomyopathy (NICM) remains a significant risk with the use of some chemotherapeutic agents. In this context, omega-3 polyunsaturated fatty acids (PUFA) have been investigated for their cardioprotective potential in rodent and in vitro models of anthracycline toxicity, with conflicting results. This study evaluated prophylactic omega-3 PUFA supplementation in a large-animal model of anthracycline-induced NICM. METHODS AND RESULTS: Merino sheep were randomized to oral drenching with omega-3 PUFA (fish oil; n 5 8) or olive oil placebo (n 5 9) 3 weeks before commencing repeated intracoronary infusions of doxorubicin (DOX) to induce cardiac dysfunction. Cumulative DOX dose was 3.6 mg/kg. Drenching was continued for 12 weeks after final DOX exposure. Despite significant increases in tissue omega-3 PUFA levels (P < .05 vs placebo), omega-3etreated sheep displayed greater signs of anthracycline cardiotoxicity than placebo animals, consisting of left ventricular dilatation and a greater decline in ejection fraction (P < .05), although myocardial fibrosis burden was similar in both groups. CONCLUSIONS: Dietary intake of omega-3 PUFA fails to prevent and may indeed exacerbate DOX-induced cardiotoxicity. Clinical use of omega-3 supplementation during chemotherapy should be deferred until more information is available regarding the mechanisms of interaction between fatty acids and the myocardium during anthracycline exposure. | - |
dc.description.statementofresponsibility | Angelo Carbone, Peter J. Psaltis, Adam J. Nelson, Robert Metcalf, James D. Richardson, Michael Weightman, Anthony Thomas, John W. Finnie, Glenn D. Young and Stephen G. Worthley | - |
dc.language.iso | en | - |
dc.publisher | Churchill Livingstone Inc Medical Publishers | - |
dc.rights | © 2012 Published by Elsevier Inc. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.cardfail.2012.03.005 | - |
dc.subject | Animal models | - |
dc.subject | cardiomyopathy | - |
dc.subject | doxorubicin, fish oil | - |
dc.title | Dietary omega-3 supplementation exacerbates left ventricular dysfunction in an ovine model of anthracycline-induced cardiotoxicity | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.cardfail.2012.03.005 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Psaltis, P. [0000-0003-0222-5468] | - |
dc.identifier.orcid | Nelson, A. [0000-0003-0990-2548] | - |
dc.identifier.orcid | Weightman, M. [0000-0001-8451-2529] | - |
dc.identifier.orcid | Finnie, J. [0000-0003-2277-1693] | - |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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