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https://hdl.handle.net/2440/73612
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Type: | Journal article |
Title: | Intraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men |
Author: | Hutchison, A. Feinle-Bisset, C. Kallas, A. Wishart, J. Clifton, P. Horowitz, M. Luscombe-Marsh, N. |
Citation: | American Journal of Clinical Nutrition, 2012; 96(3):474-482 |
Publisher: | Amer Soc Clinical Nutrition |
Issue Date: | 2012 |
ISSN: | 0002-9165 1938-3207 |
Statement of Responsibility: | Amy T. Ryan, Christine Feinle-Bisset, Asimina Kallas, Judith M. Wishart, Peter M. Clifton, Michael Horowitz and Natalie D. Luscombe-Marsh |
Abstract: | BACKGROUND: Intraduodenal fat and carbohydrate modulate antropyloroduodenal motility and hormone release and suppress appetite and energy intake in a load-dependent manner. Protein also suppresses energy intake, but its effects on these gastrointestinal factors and their role in the appetite-suppressive effects of protein remain unclear. OBJECTIVE: We aimed to characterize the effects of different intraduodenal protein loads on antropyloroduodenal pressures, gastrointestinal hormone release, glucose and insulin concentrations, appetite perceptions, and energy intake. DESIGN: Sixteen lean, healthy men were studied on 4 occasions in a randomized, double-blind fashion. Antropyloroduodenal pressures, plasma glucagon-like peptide 1 (GLP-1), cholecystokinin, peptide YY, ghrelin, blood glucose, serum insulin, and appetite were measured during 60-min, 4-mL/min intraduodenal infusions of protein at 0.5, 1.5, or 3 kcal/min or saline (control). Energy intakes at a buffet lunch consumed immediately after the infusion were quantified. RESULTS: Increases in the load of protein resulted in greater suppression of antral motility, greater stimulation of basal and isolated pyloric pressures and plasma cholecystokinin and GLP-1 concentrations, and greater suppression of energy intake. However, energy intake was reduced only after a protein load of 3 kcal/min compared with after all other treatments (P< 0.05). The suppression of energy intake after adjustment for cholecystokinin, GLP-1, and insulin was related inversely with basal pyloric pressure (r = 20.51, P < 0.001). CONCLUSION: The acute effects of intraduodenal protein on antropyloroduodenal motility, gastrointestinal hormone release, glucose, and insulin are load dependent and contribute to the suppression of energy intake. |
Keywords: | Duodenum Pyloric Antrum Humans Gastrointestinal Hormones Insulin Blood Glucose Dietary Proteins Milk Proteins Protein Hydrolysates Cross-Over Studies Double-Blind Method Energy Intake Appetite Regulation Gastrointestinal Motility Postprandial Period Adult Middle Aged New Zealand Male Young Adult Whey Proteins |
Rights: | © 2012 American Society for Nutrition |
DOI: | 10.3945/ajcn.112.038133 |
Published version: | http://dx.doi.org/10.3945/ajcn.112.038133 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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