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|Title:||Cytokine-leukocyte networks and the establishment of pregnancy|
|Citation:||American Journal of Reproductive Immunology, 1997; 37(6):438-442|
|Publisher:||MUNKSGAARD INT PUBL LTD|
|Sarah A. Robertson, Vicki J. Mau, Sarah N. Hudson, Kelton P. Tremellen|
|Abstract:||PROBLEM: Factors in seminal plasma stimulate an intense but transient inflammatory response in the murine endometrium at mating. The aim of our current studies is to delineate the cytokine-leukocyte interactions comprising this response and to elucidate the significance of these events in changes in the maternal immune system and as determinants of pregnancy outcome. METHOD: We have reviewed our recent findings. RESULTS: Transforming growth factor (TGF)-β1 has been identified as the inflammation-inducing moiety in seminal plasma. Seminal TGFβ1 initiates endometrial leukocyte infiltration by up-regulating epithelial cell expression of granulocyte-macrophage colony-stimulating factor. Other cytokines and chemokines including regulated and normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1α, MIP-1β, and monocyte chemotactic protein-1 are also implicated as mediators of macrophage and granulocyte recruitment and activation. One consequence of this inflammatory response is the induction of a transient state of hyporesponsiveness to paternal major histocompatibility class I antigens. CONCLUSION: Our studies suggest that semen may play a critical role in providing the antigenic and environmental signals necessary to initiate an appropriate maternal immune response to the conceptus during pregnancy.|
|Keywords:||GM-CSF; macrophage; seminal plasma; TGFβ tolerance; uterus|
|Rights:||© 1997 Munksgaard|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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