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https://hdl.handle.net/2440/7936
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Type: | Journal article |
Title: | Cytokine-leukocyte networks and the establishment of pregnancy |
Author: | Robertson, S. Mau, V. Hudson, S. Tremellen, K. |
Citation: | American Journal of Reproductive Immunology, 1997; 37(6):438-442 |
Publisher: | MUNKSGAARD INT PUBL LTD |
Issue Date: | 1997 |
ISSN: | 8755-8920 1600-0897 |
Statement of Responsibility: | Sarah A. Robertson, Vicki J. Mau, Sarah N. Hudson, Kelton P. Tremellen |
Abstract: | PROBLEM: Factors in seminal plasma stimulate an intense but transient inflammatory response in the murine endometrium at mating. The aim of our current studies is to delineate the cytokine-leukocyte interactions comprising this response and to elucidate the significance of these events in changes in the maternal immune system and as determinants of pregnancy outcome. METHOD: We have reviewed our recent findings. RESULTS: Transforming growth factor (TGF)-β1 has been identified as the inflammation-inducing moiety in seminal plasma. Seminal TGFβ1 initiates endometrial leukocyte infiltration by up-regulating epithelial cell expression of granulocyte-macrophage colony-stimulating factor. Other cytokines and chemokines including regulated and normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1α, MIP-1β, and monocyte chemotactic protein-1 are also implicated as mediators of macrophage and granulocyte recruitment and activation. One consequence of this inflammatory response is the induction of a transient state of hyporesponsiveness to paternal major histocompatibility class I antigens. CONCLUSION: Our studies suggest that semen may play a critical role in providing the antigenic and environmental signals necessary to initiate an appropriate maternal immune response to the conceptus during pregnancy. |
Keywords: | GM-CSF macrophage seminal plasma TGFβ tolerance uterus |
Rights: | © 1997 Munksgaard |
DOI: | 10.1111/j.1600-0897.1997.tb00257.x |
Published version: | http://dx.doi.org/10.1111/j.1600-0897.1997.tb00257.x |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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