Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8166
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Maternal thromboxane and prostacyclin levels in relation to fetal birth weight |
Author: | de Jong, C. Paarlberg, K. van Geijn, G. van Kamp, G. van Dis, H. Dekker, G. |
Citation: | European Journal of Obstetrics Gynecology and Reproductive Biology, 2000; 93(1):65-69 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2000 |
ISSN: | 0301-2115 1872-7654 |
Statement of Responsibility: | Catharina L.D. de Jong, Marieke Paarlberg, Herman P. van Geijn, Gerard J. van Kamp, Huib van Dis and Guus A. Dekker. |
Abstract: | Objective: To analyse whether pregnancies resulting in a small for gestational age neonate are preceded by a prostacyclin deficiency or an imbalance between thromboxane and prostacyclin. Study design: At five fixed time points during pregnancy, 24-h urine samples were collected for the measurement of thromboxane and prostacyclin metabolites thromboxane-B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α). In order to study trend differences between pregnancies with appropriate (AGA; n=26) and small for gestational age neonates (SGA; n=17), trend analysis with simple contrasts were accomplished for TXB2, 6-keto-PGF1α and the TXB2/6-keto-PGF1α ratio. Results: Trend analysis showed higher TXB2 levels and higher TXB2/6-keto-PGF1α ratios in patients with SGA versus AGA newborns. No statistically significant difference in 6-keto-PGF1α excretion between patients with SGA and AGA newborns was detected. Conclusion: The birth of an SGA neonate is not preceded by prostacyclin deficiency. With ongoing pregnancy an imbalance between thromboxane and prostacyclin becomes more obvious in pregnancies with SGA newborns. |
Keywords: | Humans Pre-Eclampsia Birth Weight 6-Ketoprostaglandin F1 alpha Thromboxane B2 Gestational Age Pregnancy Adult Infant, Newborn Infant, Small for Gestational Age Female |
Description: | Copyright © 2000 Elsevier Science Ireland Ltd. All rights reserved. |
DOI: | 10.1016/S0301-2115(00)00266-9 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/505961/description#description |
Published version: | http://dx.doi.org/10.1016/s0301-2115(00)00266-9 |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.