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https://hdl.handle.net/2440/8574
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dc.contributor.author | Holloway, R. | - |
dc.contributor.author | Penagini, R. | - |
dc.contributor.author | Ireland, A. | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | American Journal of Physiology, 1995; 268(1):G128-G133 | - |
dc.identifier.issn | 0002-9513 | - |
dc.identifier.issn | 2163-5773 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8574 | - |
dc.description.abstract | We developed and evaluated objective manometric criteria that define transient lower esophageal sphincter (LES) relaxation. In 23 normal subjects and 9 patients with gastroesophageal reflux disease, systematic analysis of swallow-induced LES relaxation showed that dry swallows preceded LES relaxation by a median of 1.4 s. The relaxation rate was always > 1 mmHg/s, the relaxation nadir always occurred within 7 s, and the duration of relaxation was < 9 s. During concurrent esophageal manometry and pH monitoring, 104 reflux episodes associated with a LES pressure fall that was not related to swallowing were identified and the pressure falls classified as transient LES relaxations or not by visual recognition. LES pressure was always < or = 2 mmHg at time of reflux, and relaxation was significantly longer than for swallow-induced LES relaxation. Of 88 pressure falls classified visually as transient LES relaxations, 90% reached nadir pressure within 7 s at a rate of > 1 mmHg/s. Sixteen pressure falls were classified as a gradual downward drift in LES pressure, which in 15 cases was < 1 mmHg/s. Based on the analysis, transient LES relaxation can be defined by 1) absence of swallowing for 4 s before to 2 s after the onset of LES relaxation, 2) relaxation rate of > or = 1 mmHg/s, 3) time from onset to complete relaxation of < or = 10 s, and 4) nadir pressure of < or = 2 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS) | - |
dc.description.statementofresponsibility | Richard H. Holloway, Roberto Penagini, and Alan C. Ireland | - |
dc.language.iso | en | - |
dc.publisher | American Physiological Society | - |
dc.rights | Copyright © 1995 the American Physiological Society | - |
dc.source.uri | http://ajpgi.physiology.org/content/268/1/G128 | - |
dc.subject | Esophagogastric Junction | - |
dc.subject | Humans | - |
dc.subject | Gastroesophageal Reflux | - |
dc.subject | Deglutition | - |
dc.subject | Muscle Relaxation | - |
dc.subject | Pressure | - |
dc.subject | Time Factors | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Terminology as Topic | - |
dc.title | Criteria for the objective definition of transient lower esophageal sphincter relaxation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpgi.1995.268.1.g128 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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