Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/85895
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Type: | Journal article |
Title: | Tailored immune responses: novel effector helper T cell subsets in protective immunity |
Author: | Kara, E. Comerford, I. Fenix, K. Bastow, C. Gregor, C. McKenzie, D. McColl, S. |
Citation: | PLoS Pathogens, 2014; 10(2):1003905-1-1003905-15 |
Publisher: | Public Library of Science |
Issue Date: | 2014 |
ISSN: | 1553-7374 1553-7374 |
Editor: | Hobman, T.C. |
Statement of Responsibility: | Ervin E. Kara, Iain Comerford, Kevin A. Fenix, Cameron R. Bastow, Carly E. Gregor, Duncan R. McKenzie, Shaun R. McColl |
Abstract: | Differentiation of naïve CD4+ cells into functionally distinct effector helper T cell subsets, characterised by distinct “cytokine signatures,” is a cardinal strategy employed by the mammalian immune system to efficiently deal with the rapidly evolving array of pathogenic microorganisms encountered by the host. Since the TH1/TH2 paradigm was first described by Mosmann and Coffman, research in the field of helper T cell biology has grown exponentially with seven functionally unique subsets having now been described. In this review, recent insights into the molecular mechanisms that govern differentiation and function of effector helper T cell subsets will be discussed in the context of microbial infections, with a focus on how these different helper T cell subsets orchestrate immune responses tailored to combat the nature of the pathogenic threat encountered. |
Keywords: | T-Lymphocyte Subsets T-Lymphocytes, Helper-Inducer Animals Humans Cell Differentiation Adaptive Immunity |
Rights: | © 2014 Kara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.ppat.1003905 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1009002 |
Published version: | http://dx.doi.org/10.1371/journal.ppat.1003905 |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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hdl_85895.pdf | Published version | 810.11 kB | Adobe PDF | View/Open |
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