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Type: Journal article
Title: Genetic diversity and virulence potential of shiga toxin-producing Escherichia coli O113: H21 strains isolated from clinical, environmental, and food sources
Author: Feng, P.
Delannoy, S.
Lacher, D.
dos Santos, L.
Beutin, L.
Fach, P.
Rivas, M.
Hartland, E.
Paton, A.
Guth, B.
Citation: Applied and Environmental Microbiology, 2014; 80(15):4757-4763
Publisher: American Society for Microbiology
Issue Date: 2014
ISSN: 0099-2240
Statement of
Peter C. H. Feng, Sabine Delannoy, David W. Lacher, Luis Fernando dos Santos, Lothar Beutin, Patrick Fach, Marta Rivas, Elizabeth L. Hartland, Adrienne W. Paton and Beatriz E. C. Guth
Abstract: Shiga toxin-producing Escherichia coli strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains.
Keywords: Feces; Animals; Cattle; Goats; Dogs; Humans; Escherichia coli Infections; Escherichia coli Proteins; Shiga Toxin; Virulence Factors; Environmental Microbiology; Food Microbiology; Phylogeny; Meat; Molecular Sequence Data; Shiga-Toxigenic Escherichia coli; Genetic Variation
Description: Published ahead of print 23 May 2014
Rights: © 2014, American Society for Microbiology. All Rights Reserved.
RMID: 0030009354
DOI: 10.1128/AEM.01182-14
Appears in Collections:Molecular and Biomedical Science publications

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