Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8617
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Type: Journal article
Title: A positron emission tomography study of cerebral activation associated with essential and writing tremor
Author: Wills, A.
Jenkins, I.
Thompson, P.
Findley, L.
Brooks, D.
Citation: Archives of Neurology, 1995; 52(3):299-305
Publisher: American Medical Association
Issue Date: 1995
ISSN: 0003-9942
1538-3687
Abstract: OBJECTIVE: To compare the abnormal patterns of cerebral activation associated with essential and writing tremors. DESIGN: Positron emission tomography using oxygen 15-labeled water was utilized to determine regional cerebral blood flow. Positron emission tomography images that were taken of the brain in individual patients were coregistered with magnetic resonance images of the same brain to ascertain accurate localization of cerebral activation in single patients. Patients with essential tremor underwent scanning at rest, during involuntary postural tremor, and during passive wrist oscillation. Normal control subjects underwent scanning at rest and during voluntary and passive wrist oscillation. Patients with writing tremor underwent scanning while they were holding a pen to paper with consequent involuntary tremor and again while they were holding a pen in the same supinated arm without tremor. SETTING: Research hospital. PATIENTS OR OTHER PARTICIPANTS: Seven patients with essential tremor, six patients with writing tremor, and six matched control subjects. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Regional cerebral blood flow. RESULTS: Essential tremor was associated with abnormal bilateral cerebellar, red nuclear, and thalamic activation. Writing tremor was also associated with abnormal bilateral cerebellar activation. Voluntary wrist oscillation in control subjects caused only ipsilateral cerebellar activation. These findings were evident in single patients, when positron emission tomography images were coregistered with magnetic resonance images and on group analysis of the pooled positron emission tomography data after transformation into stereotaxic space. CONCLUSION: These results indicate that both essential and writing tremors are associated with abnormal bilateral overactivity of cerebellar connections.
Keywords: Hand; Wrist; Brain; Cerebellum; Thalamus; Humans; Tremor; Tomography, Emission-Computed; Brain Mapping; Cerebrovascular Circulation; Writing; Adult; Aged; Middle Aged; Female; Male
RMID: 0030005108
DOI: 10.1001/archneur.1995.00540270095025
Appears in Collections:Medicine publications

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