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https://hdl.handle.net/2440/86998
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Type: | Journal article |
Title: | Radiofrequency-triggered release for on-demand delivery of therapeutics from titania nanotube drug-eluting implants |
Author: | Bariana, M. Aw, M. Moore, E. Voelcker, N. Losic, D. |
Citation: | Nanomedicine, 2014; 9(8):1263-1275 |
Publisher: | Future Medicine |
Issue Date: | 2014 |
ISSN: | 1743-5889 1748-6963 |
Statement of Responsibility: | Manpreet Bariana, Moom Sinn Aw, Eli Moore, Nicolas H Voelcker, Dusan Losic |
Abstract: | AIM: This study aimed to demonstrate radiofrequency (RF)-triggered release of drugs and drug carriers from drug-eluting implants using gold nanoparticles as energy transducers. MATERIALS & METHODS: Titanium wire with a titania nanotube layer was used as an implant loaded with indomethacin and micelles (tocopheryl PEG succinate) as a drug and drug carrier model. RF signals were generated from a customized RF generator to trigger in vitro release. RESULTS & DISCUSSION: Within 2.5 h, 18 mg (92%) of loaded drug and 14 mg (68%) of loaded drug carriers were released using short RF exposure (5 min), compared with 5 mg (31%) of drug and 2 mg (11%) of drug carriers without a RF trigger. Gold nanoparticles can effectively function as RF energy transducers inside titania nanotubes for rapid release of therapeutics at arbitrary times. CONCLUSION: The results of this study show that RF is a promising strategy for triggered release from implantable drug delivery systems where on-demand delivery of therapeutics is required. |
Keywords: | drug-eluting implant gold nanoparticle micelle noninvasive drug delivery polymer radiofrequency titania nanotube triggered drug release water-insoluble drug |
Rights: | Copyright status unknown |
DOI: | 10.2217/nnm.13.93 |
Grant ID: | http://purl.org/au-research/grants/arc/FT110100711 http://purl.org/au-research/grants/arc/DP120101680 |
Published version: | http://dx.doi.org/10.2217/nnm.13.93 |
Appears in Collections: | Aurora harvest 7 Chemical Engineering publications |
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