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https://hdl.handle.net/2440/8859
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dc.contributor.author | Russo, A. | - |
dc.contributor.author | Sun, W.M. | - |
dc.contributor.author | Sattawatthamrong, Y. | - |
dc.contributor.author | Fraser, R. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Boeckxstaens, G. | - |
dc.contributor.author | Andrews, J. | - |
dc.contributor.author | Read, N. | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Gut, 1997; 41(4):494-499 | - |
dc.identifier.issn | 0017-5749 | - |
dc.identifier.issn | 1468-3288 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8859 | - |
dc.description.abstract | <h4>Background</h4>The pathogenesis of anorectal dysfunction, which occurs frequently in patients with diabetes mellitus, is poorly defined. Recent studies indicate that changes in the blood glucose concentration have a major reversible effect on gastrointestinal motor function.<h4>Aims</h4>To determine the effects of physiological changes in blood glucose and hyperglycaemia on anorectal motor and sensory function in normal subjects.<h4>Subjects</h4>In eight normal subjects measurements of anorectal motility and sensation were performed on separate days while blood glucose concentrations were stabilised at 4, 8, and 12 mmol/l.<h4>Methods</h4>Anorectal motor and sensory function was measured using a sleeve/sidehole catheter incorporating a balloon, and electromyography.<h4>Results</h4>The number of spontaneous anal relaxations was greater at 12 mmol/l than at 8 and 4 mmol/l glucose (p < 0.05 for both). Anal squeeze pressures were less at a blood glucose of 12 mmol/l when compared with 8 and 4 mmol/l (p < 0.05 for both). During rectal distension, residual anal pressures were not significantly different between the three blood glucose concentrations. Rectal compliance was greater (p < 0.05) at a blood glucose of 12 mmol/l when compared with 4 mmol/l. The threshold volume for initial perception of rectal distension was less at 12 mmol/l when compared with 4 mmol/l (40 (20-100) ml versus 10 (10-150) ml, p < 0.05).<h4>Conclusions</h4>An acute elevation of blood glucose to 12 mmol/l inhibits internal and external anal sphincter function and increases rectal sensitivity in normal subjects. In contrast, physiological changes in blood glucose do not have a significant effect on anorectal motor and sensory function. | - |
dc.description.statementofresponsibility | A Russo, W M Sun, Y Sattawatthamrong, R Fraser, M Horowitz, J M Andrews, N W Read | - |
dc.language.iso | en | - |
dc.publisher | BRITISH MED JOURNAL PUBL GROUP | - |
dc.source.uri | http://dx.doi.org/10.1136/gut.41.4.494 | - |
dc.subject | Rectum | - |
dc.subject | Humans | - |
dc.subject | Hyperglycemia | - |
dc.subject | Acute Disease | - |
dc.subject | Glucose Clamp Technique | - |
dc.subject | Analysis of Variance | - |
dc.subject | Statistics, Nonparametric | - |
dc.subject | Single-Blind Method | - |
dc.subject | Manometry | - |
dc.subject | Sensory Thresholds | - |
dc.subject | Gastrointestinal Motility | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Anal Canal | - |
dc.subject | Male | - |
dc.title | Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1136/gut.41.4.494 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Andrews, J. [0000-0001-7960-2650] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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