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https://hdl.handle.net/2440/9224
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dc.contributor.author | Jones, K. | - |
dc.contributor.author | Russo, A. | - |
dc.contributor.author | Berry, M. | - |
dc.contributor.author | Stevens, J. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | American Journal of Medicine, 2002; 113(6):449-455 | - |
dc.identifier.issn | 0002-9343 | - |
dc.identifier.issn | 1555-7162 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9224 | - |
dc.description.abstract | <h4>Purpose</h4>To evaluate the natural history of gastric emptying and upper gastrointestinal symptoms in patients with diabetes mellitus.<h4>Subjects and methods</h4>We enrolled 20 patients (6 men, 14 women) with diabetes mellitus (16 with type 1 diabetes, 4 with type 2 diabetes). Each had measurements of gastric emptying of a solid (100 g of ground beef) and liquid (150 mL of 10% dextrose) meal using scintigraphy, glycemic control (glycosylated hemoglobin [HbA(1c)] and mean blood glucose levels), upper gastrointestinal symptoms, and autonomic nerve function at baseline and after a mean (+/- SD) of 12.3 +/- 3.1 years of follow-up.<h4>Results</h4>There were no differences in mean gastric emptying of the solid component (retention at 100 minutes at baseline: 56% +/- 19% vs. follow-up: 51% +/- 21%, P = 0.23) or the liquid component (time for 50% to empty at baseline: 33 +/- 11 minutes vs. follow-up: 31 +/- 12 minutes, P = 0.71) during follow-up. Mean blood glucose (17.0 +/- 5.6 mmol/L vs. 13.8 +/- 4.9 mmol/L, P = 0.007) and HbA(1c) (8.4% +/- 2.3% vs. 7.6% +/- 1.3%, P = 0.03) levels were lower at follow-up. There was no difference in symptom score (baseline: 3.9 +/- 2.7 vs. follow-up: 4.2 +/- 4.0, P = 0.78). There was evidence of autonomic neuropathy in 7 patients (35%) at baseline and 16 (80%) at follow-up.<h4>Conclusion</h4>In patients with diabetes mellitus, we did not observe any marked changes in either gastric emptying or upper gastrointestinal symptoms during a 12-year period. | - |
dc.description.statementofresponsibility | Karen L. Jones, Antonietta Russo, Melanie K. Berry, Julie E. Stevens, Judith M. Wishart, Michael Horowitz | - |
dc.language.iso | en | - |
dc.publisher | Excerpta Medica Inc | - |
dc.rights | Copyright © 2002 by Excerpta Medica, Inc. | - |
dc.source.uri | http://dx.doi.org/10.1016/s0002-9343(02)01228-7 | - |
dc.subject | Humans | - |
dc.subject | Gastrointestinal Diseases | - |
dc.subject | Gastroparesis | - |
dc.subject | Diabetic Neuropathies | - |
dc.subject | Diabetes Mellitus | - |
dc.subject | Diabetes Complications | - |
dc.subject | Blood Glucose | - |
dc.subject | Longitudinal Studies | - |
dc.subject | Gastric Emptying | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | A longitudinal study of gastric emptying and upper gastrointestinal symptoms in patients with diabetes mellitus | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0002-9343(02)01228-7 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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