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https://hdl.handle.net/2440/9243
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Type: | Journal article |
Title: | Triggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen |
Author: | Staunton, E. Smid, S. Dent, J. Blackshaw, L. |
Citation: | American Journal of Physiology: Gastrointestinal and Liver Physiology, 2000; 279(1 42-1):G157-G162 |
Publisher: | Amer Physiological Soc |
Issue Date: | 2000 |
ISSN: | 0193-1857 1522-1547 |
Abstract: | Activation of gastric vagal mechanoreceptors by distention is thought to be the trigger for transient lower esophageal sphincter relaxations (TLESR), which lead to gastroesophageal reflux. The contribution of higher-threshold gastric splanchnic mechanoreceptors is uninvestigated. GABA(B) receptor agonists, including baclofen, potently reduce triggering of TLESR by low-level gastric distention. We aimed to determine first whether this effect of baclofen is maintained at high-level distention and second the role of splanchnic pathways in triggering TLESR. Micromanometric/pH studies in conscious ferrets showed that intragastric glucose infusion (25 ml) increased triggering of TLESR and reflux. Both were significantly reduced by baclofen (7 micromol/kg ip) (P < 0.05). When 40 ml of air was added to the glucose infusion, more TLESR occurred than with glucose alone (P < 0.01). These were also reduced by baclofen (P < 0.001). TLESR after glucose/air infusion were assessed before and after splanchnectomy (2-4, 9-11, and 23-25 days), which revealed no change. Baclofen inhibits TLESR after both low- and high-level gastric distention. Splanchnic pathways do not contribute to increased triggering of TLESR by high-level gastric distention. |
Keywords: | Muscle, Smooth Esophagogastric Junction Splanchnic Nerves Animals Ferrets Gastroesophageal Reflux Baclofen Capsaicin Glucose Receptors, GABA-B Muscle Relaxants, Central Muscle Denervation Eating Pressure Female |
DOI: | 10.1152/ajpgi.2000.279.1.g157 |
Published version: | http://dx.doi.org/10.1152/ajpgi.2000.279.1.g157 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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