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|Title:||Effects of acute hyperglycaemia on anorectal motor and sensory function in diabetes mellitus|
|Citation:||Diabetic Medicine, 2004; 21(2):176-182|
|Publisher:||Blackwell Publishing Ltd|
|A. Russo, R. Botten, M.-F. Kong, I. M. Chapman, R. J. L. Fraser, M. Horowitz and W.-M. Sun|
|Abstract:||AIMS:To determine the effects of acute hyperglycaemia on anorectal motor and sensory function in patients with diabetes mellitus. METHODS:In eight patients with Type 1, and 10 patients with Type 2 diabetes anorectal motility and sensation were evaluated on separate days while the blood glucose concentration was stabilized at either 5 mmol/l or 12 mmol/l using a glucose clamp technique. Eight healthy subjects were studied under euglycaemic conditions. Anorectal motor and sensory function was evaluated using a sleeve/sidehole catheter, incorporating a barostat bag. RESULTS:In diabetic subjects hyperglycaemia was associated with reductions in maximal (P<0.05) and plateau (P<0.05) anal squeeze pressures and the rectal pressure/volume relationship (compliance) during barostat distension (P<0.01). Hyperglycaemia had no effect on the perception of rectal distension. Apart from a reduction in rectal compliance (P<0.01) and a trend (P=0.06) for an increased number of spontaneous anal sphincter relaxations, there were no differences between the patients studied during euglycaemia when compared with healthy subjects. CONCLUSIONS:In patients with diabetes, acute hyperglycaemia inhibits external anal sphincter function and decreases rectal compliance, potentially increasing the risk of faecal incontinence.|
|Keywords:||anorectal motility; hyperglycaemia; faecal incontinence|
|Description:||© 2004 Diabetes UK. Diabetic Medicine. The definitive version is available at www.blackwell-synergy.com|
|Appears in Collections:||Medicine publications|
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