Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/94832
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Type: Journal article
Title: Intracellular microenvironment-responsive dendrimer-like mesoporous nanohybrids for traceable, effective, and safe gene delivery
Author: Du, X.
Xiong, L.
Dai, S.
Kleitz, F.
Zhang Qiao, S.
Citation: Advanced Functional Materials, 2014; 24(48):7627-7637
Publisher: Wiley
Issue Date: 2014
ISSN: 1616-301X
1616-3028
Statement of
Responsibility: 
Xin Du, Lin Xiong, Sheng Dai, Freddy Kleitz, and Shi Zhang Qiao
Abstract: In order to create advanced functional nanocarriers for efficient gene therapy, novel intracellular microenvironment-sensitive fluorescence label-free nanostructured dendrimer-like silica hybrid nanocarriers are developed for traceable, effective, and safe gene delivery. Dendrimer-like mesoporous silica nanoparticles (DMSNs) with center-radial large pores are covalently modified with short polyethyleneimine (PEI) for efficient gene loading and binding. Autofluorescent and biodegradable PEI (AC-PEI) responsive to the intracellular microenvironment are then coated on the gene-loaded nanoparticles for inhibiting gene leakage from the carriers. Moreover, AC-PEI coating not only endows intracellular microenvironment-responsive gene release property, but also allows monitoring the gene delivery process in the absence of external labelling, owing to the pH- and GSH-responsive autofluorescence and biodegradability of AC-PEI. The resultant nanocarriers show high gene loading capacity, low cytotoxicity, stimuli-responsive gene release, label-free, and simultaneous fluorescence tracking, and high gene silencing capability. Thus, these developed nanocarriers hold substantial and promising potential as effective and safe gene-delivery carriers for future scientific investigation and practical implications in gene therapy.
Description: Article first published online: 6 OCT 2014
Rights: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
RMID: 0030016559
DOI: 10.1002/adfm.201402408
Grant ID: http://purl.org/au-research/grants/arc/DP140104062
http://purl.org/au-research/grants/arc/DP130104459
http://purl.org/au-research/grants/arc/DP110102877
Appears in Collections:Chemical Engineering publications

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