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https://hdl.handle.net/2440/95431
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Type: | Journal article |
Title: | Vitamin-D regulation of bone mineralization and remodelling during growth |
Author: | Morris, H. Turner, A. Anderson, P. |
Citation: | Frontiers in Bioscience (Elite Edition), 2012; E4(2):677-689 |
Publisher: | Frontiers in Bioscience |
Issue Date: | 2012 |
ISSN: | 1945-0494 1945-0508 |
Statement of Responsibility: | Howard A Morris, Andrew G Turner, Paul H Anderson |
Abstract: | Vitamin D status relates to two bone diseases, osteomalacia and osteoporosis which arise from distinct pathophysiogical pathways. They can occur in children as well as adults. Osteomalacia or rickets arises from a delay in mineralization and can be caused by severe vitamin D deficiency where the key to curing osteomalacia is the endocrine action of circulating 1,25-dihydroxyvitamin D to normalize the active intestinal transport of calcium and phosphate. Osteoporosis or sub-optimal bone mineral accretion during growth is a risk factor for fracture in children. Current evidence suggests serum 25- hydroxyvitamin D levels between 20 and 80 nmol/L are associated with decreased bone mineral content as a result, at least partly, of reduced vitamin D metabolism and activity within bone cells. The local synthesis of 1,25- dihydroxyvitamin D within bone is necessary to modulate bone resorption and promote bone formation. Thus an adequate vitamin D status is necessary for vitamin D activity within bone to establish a healthy skeleton. |
Keywords: | Vitamin D metabolism; CYP27B1; CYP 24; bone cell activities; osteomalacia; osteoporosis; vitamin D actvities; review |
Rights: | Copyright © Frontiers in Bioscience |
DOI: | 10.2741/409 |
Published version: | https://www.bioscience.org/2012/v4e/af/409/fulltext.htm |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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