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https://hdl.handle.net/2440/9741
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dc.contributor.author | Feinle-Bisset, C. | - |
dc.contributor.author | Chapman, I. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Peptides, 2002; 23(8):1491-1495 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.issn | 1873-5169 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9741 | - |
dc.description | Copyright © 2002 Elsevier Science Inc. All rights reserved. | - |
dc.description.abstract | It has been suggested that obesity is associated with a reduced glucagon-like peptide-1 (GLP-1) response to oral carbohydrate, but not fat. The latter may, however, be attributable to changes in gastric emptying. We have assessed plasma GLP-1 levels in response to these infusions in lean and obese subjects. Seven healthy lean (body mass index (BMI), 19.1-24.6 kg/m(2)) and seven obese (BMI, 31.3-40.8 kg/m(2)) young men received an intraduodenal infusion of glucose and fat for 120 min (2.86 kcal/min) on two separate days. Blood samples for plasma GLP-1 were obtained at baseline and every 20 min during the infusion. Plasma GLP-1 increased during infusion of glucose and fat (P = 0.001), but there were no differences between lean and obese subjects, nor the two nutrients. We conclude that GLP-1 secretion in response to duodenal infusion of glucose and fat is not altered in obese subjects. | - |
dc.description.statementofresponsibility | Christine Feinle, Ian M. Chapman, Judith Wishart, Michael Horowitz | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/s0196-9781(02)00087-6 | - |
dc.subject | Glucagon-like peptide-1 | - |
dc.subject | Obesity | - |
dc.subject | Glucose | - |
dc.subject | Fat | - |
dc.subject | Duodenal infusion | - |
dc.title | Plasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese men | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0196-9781(02)00087-6 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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