Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9772
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kumar, S. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Science's STKE : signal transduction knowledge environment, 2004; 254(254):1-4 | - |
dc.identifier.issn | 1525-8882 | - |
dc.identifier.issn | 1525-8882 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9772 | - |
dc.description.abstract | Caspases, the cysteine proteases that cleave their substrates following an aspartate residue, primarily carry out two distinct functions: (i) activation of proinflammatory cytokines and (ii) execution of apoptosis. These two functions are considered to be unique to individual caspases; thus, some caspases act in apoptosis, whereas others have a role in inflammation. However, this dogma is now being challenged as nonapoptotic functions are ascribed to caspases that, until recently, were only known to function in cell death pathways. Recent work suggests that DRONC, the only initiator cell death caspase in Drosophila, may play a direct or indirect role in cell migration, sperm differentiation, and cell proliferation in addition to its function in cell death. | - |
dc.language.iso | en | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.subject | Animals | - |
dc.subject | Caspases | - |
dc.subject | Cell Division | - |
dc.subject | Apoptosis | - |
dc.subject | Cell Differentiation | - |
dc.subject | Cell Movement | - |
dc.title | Migrate, differentiate, proliferate, or die: pleiotropic functions of an apical 'apoptotic caspase' | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1126/stke.2542004pe49 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.