Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9791
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Type: Journal article
Title: Effect of Perindopril on platelet nitric oxide resistance in patients with chronic heart failure secondary to ischemic left ventricular dysfunction
Author: Chirkov, Y.
Holmes, A.
Martelli, J.
Horowitz, J.
Citation: American Journal of Cardiology, 2004; 93(11):1438-1440
Publisher: Excerpta Medica Inc
Issue Date: 2004
ISSN: 0002-9149
1879-1913
Statement of
Responsibility: 
Yuliy Y. Chirkov, Andrew S. Holmes, Jason D. Martelli, and John D. Horowitz
Abstract: In 15 patients with chronic heart failure of ischemic origin who were not previously treated with angiotensin-converting enzyme inhibitors, platelets exhibited hyperaggregability and impaired responsiveness to the antiaggregatory and cyclic guanosine monophosphate-stimulatory effects of nitric oxide donor sodium nitroprusside compared with normal subjects; this was paralleled by increased blood levels of superoxide radicals. Treatment with perindopril for 4 days significantly improved platelet responses to sodium nitroprusside; there was also a trend toward a decrease in superoxide radical levels.
Keywords: Humans; Ventricular Dysfunction, Left; Nitroprusside; Superoxides; Nitric Oxide; Perindopril; Cyclic GMP; Nitric Oxide Donors; Angiotensin-Converting Enzyme Inhibitors; Platelet Function Tests; Platelet Aggregation; Time Factors; Middle Aged; Female; Male; Heart Failure
Description: Copyright © 2004 Excerpta Medica Inc. All rights reserved.
RMID: 0020040535
DOI: 10.1016/j.amjcard.2004.02.052
Appears in Collections:Medicine publications

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