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https://hdl.handle.net/2440/9791
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Type: | Journal article |
Title: | Effect of Perindopril on platelet nitric oxide resistance in patients with chronic heart failure secondary to ischemic left ventricular dysfunction |
Author: | Chirkov, Y. Holmes, A. Martelli, J. Horowitz, J. |
Citation: | American Journal of Cardiology, 2004; 93(11):1438-1440 |
Publisher: | Excerpta Medica Inc |
Issue Date: | 2004 |
ISSN: | 0002-9149 1879-1913 |
Statement of Responsibility: | Yuliy Y. Chirkov, Andrew S. Holmes, Jason D. Martelli, and John D. Horowitz |
Abstract: | In 15 patients with chronic heart failure of ischemic origin who were not previously treated with angiotensin-converting enzyme inhibitors, platelets exhibited hyperaggregability and impaired responsiveness to the antiaggregatory and cyclic guanosine monophosphate-stimulatory effects of nitric oxide donor sodium nitroprusside compared with normal subjects; this was paralleled by increased blood levels of superoxide radicals. Treatment with perindopril for 4 days significantly improved platelet responses to sodium nitroprusside; there was also a trend toward a decrease in superoxide radical levels. |
Keywords: | Humans Ventricular Dysfunction, Left Nitroprusside Superoxides Nitric Oxide Perindopril Cyclic GMP Nitric Oxide Donors Angiotensin-Converting Enzyme Inhibitors Platelet Function Tests Platelet Aggregation Time Factors Middle Aged Female Male Heart Failure |
Description: | Copyright © 2004 Excerpta Medica Inc. All rights reserved. |
DOI: | 10.1016/j.amjcard.2004.02.052 |
Published version: | http://dx.doi.org/10.1016/j.amjcard.2004.02.052 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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