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|Title:||Effect of Perindopril on platelet nitric oxide resistance in patients with chronic heart failure secondary to ischemic left ventricular dysfunction|
|Citation:||American Journal of Cardiology, 2004; 93(11):1438-1440|
|Publisher:||Excerpta Medica Inc|
|Yuliy Y. Chirkov, Andrew S. Holmes, Jason D. Martelli, and John D. Horowitz|
|Abstract:||In 15 patients with chronic heart failure of ischemic origin who were not previously treated with angiotensin-converting enzyme inhibitors, platelets exhibited hyperaggregability and impaired responsiveness to the antiaggregatory and cyclic guanosine monophosphate-stimulatory effects of nitric oxide donor sodium nitroprusside compared with normal subjects; this was paralleled by increased blood levels of superoxide radicals. Treatment with perindopril for 4 days significantly improved platelet responses to sodium nitroprusside; there was also a trend toward a decrease in superoxide radical levels.|
|Keywords:||Humans; Ventricular Dysfunction, Left; Nitroprusside; Superoxides; Nitric Oxide; Perindopril; Cyclic GMP; Nitric Oxide Donors; Angiotensin-Converting Enzyme Inhibitors; Platelet Function Tests; Platelet Aggregation; Time Factors; Middle Aged; Female; Male; Heart Failure|
|Description:||Copyright © 2004 Excerpta Medica Inc. All rights reserved.|
|Appears in Collections:||Medicine publications|
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