Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99131
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Type: Journal article
Title: Low cytotoxic trace element selenium nanoparticles and their differential antimicrobial properties against S. aureus and E. coli
Author: Tran, P.
O'Brien-Simpson, N.
Reynolds, E.
Pantarat, N.
Biswas, D.
O'Connor, A.
Citation: Nanotechnology, 2015; 27(4):045101-1-045101-10
Publisher: IOP Publishing
Issue Date: 2015
ISSN: 1361-6528
1361-6528
Statement of
Responsibility: 
Phong A Tran, Neil O'Brien-Simpson, Eric C Reynolds, Namfon Pantarat, Dhee P Biswas and Andrea J O'Connor
Abstract: Antimicrobial agents that have no or low cytotoxicity and high specificity are desirable to have no or minimal side effects. We report here the low cytotoxicity of polyvinyl alcohol-stabilized selenium (Se) nanoparticles and their differential effects on growth of S. aureus, a gram-positive bacterium and E. coli, a gram-negative bacterium. The nanoparticles were synthesised through redox reactions in an aqueous environment at room temperature and were characterised using UV visible spectrophotometry, transmission electron microscopy, dynamic light scattering and x-ray photoelectron spectroscopy. The nanoparticles showed low toxicity toward fibroblasts which remained more than 70% viable at Se concentrations as high as 128 ppm. The nanoparticles also exhibited very low haemolysis with only 18% of maximal lysis observed at a Se concentration of 128 ppm. Importantly, the nanoparticles showed strong growth inhibition toward S. aureus at a concentration as low as 1 ppm. Interestingly, growth of E. coli was unaffected at all concentrations tested. This study therefore strongly suggests that these nanoparticles should be investigated further to understand this differential effect as well as for potential advanced antimicrobial applications such as S. aureus infection-resisting, non-cytotoxic coatings for medical devices.
Keywords: 3T3 Cells; Fibroblasts; Animals; Horses; Humans; Mice; Escherichia coli; Staphylococcus aureus; Escherichia coli Infections; Staphylococcal Infections; Hemolysis; Selenium; Anti-Bacterial Agents; Microbial Sensitivity Tests; Cell Survival; Metal Nanoparticles
Rights: © 2016 IOP Publishing Ltd
RMID: 0030048055
DOI: 10.1088/0957-4484/27/4/045101
Appears in Collections:Medicine publications

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