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https://hdl.handle.net/2440/99328
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Type: | Journal article |
Title: | Old, new and emerging functions of caspases |
Author: | Shalini, S. Dorstyn, L. Dawar, S. Kumar, S. |
Citation: | Cell Death and Differentiation, 2015; 22(4):526-539 |
Publisher: | Nature Publishing Group |
Issue Date: | 2015 |
ISSN: | 1350-9047 1476-5403 |
Statement of Responsibility: | S Shalini, L Dorstyn, S Dawar and S Kumar |
Abstract: | Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and caspase-11 have roles in inflammation and mediating inflammatory cell death by pyroptosis. Similarly, caspase-8 has dual role in cell death, mediating both receptor-mediated apoptosis and in its absence, necroptosis. Caspase-8 also functions in maintenance and homeostasis of the adult T-cell population. Caspase-3 has important roles in tissue differentiation, regeneration and neural development in ways that are distinct and do not involve any apoptotic activity. Several other caspases have demonstrated anti-tumor roles. Notable among them are caspase-2, -8 and -14. However, increased caspase-2 and -8 expression in certain types of tumor has also been linked to promoting tumorigenesis. Increased levels of caspase-3 in tumor cells causes apoptosis and secretion of paracrine factors that promotes compensatory proliferation in surrounding normal tissues, tumor cell repopulation and presents a barrier for effective therapeutic strategies. Besides this caspase-2 has emerged as a unique caspase with potential roles in maintaining genomic stability, metabolism, autophagy and aging. The present review focuses on some of these less studied and emerging functions of mammalian caspases. |
Keywords: | Animals Humans Genomic Instability Caspases Inflammation Mediators Regeneration Apoptosis Cell Differentiation Carcinogenesis |
Rights: | © 2015 Macmillan Publishers Limited All rights reserved. |
DOI: | 10.1038/cdd.2014.216 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1021456 http://purl.org/au-research/grants/nhmrc/1041807 http://purl.org/au-research/grants/nhmrc/1043057 http://purl.org/au-research/grants/nhmrc/1002863 |
Published version: | http://dx.doi.org/10.1038/cdd.2014.216 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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