Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9934
Type: | Journal article |
Title: | Increased severity of lower urinary tract symptoms and daytime somnolence in primary Sjögren's syndrome |
Other Titles: | Increased severity of lower urinary tract symptoms and daytime somnolence in primary Sjogren's syndrome |
Author: | Walker, J. Gordon, T. Lester, S. Downie-Doyle, S. McEvoy, R. Pile, K. Waterman, S. Rischmueller, M. |
Citation: | Journal of Rheumatology, 2003; 30(11):2406-2412 |
Publisher: | J Rheumatol Publ Co |
Issue Date: | 2003 |
ISSN: | 0315-162X 1499-2752 |
Statement of Responsibility: | Jennifer Walker, Tom Gordon,Sue Lester, Sarah Downie-Doyle, Doug McEvoy, Kevin Pile, Sally Waterman and Maureen Rischmueller |
Abstract: | OBJECTIVE: Functional antimuscarinic receptor autoantibodies have recently been described in both primary and secondary Sjögren's syndrome (SS) in a mouse bladder contraction assay. Most patients with these antibodies complained of severe lower urinary tract disturbances, which are not a recognized feature of SS. We compared the severity of self-reported urological symptoms, daytime somnolence, and fatigue between a cohort of patients with primary SS and controls with osteoarthritis (OA). METHODS: Female patients were recruited from rheumatology outpatient clinics at 2 hospitals. The American Urological Symptom Index (AUA-7), Epworth Sleepiness Scale, and FACIT-F fatigue self-administered instruments were employed. Results were obtained for 76 patients with primary SS and 43 controls (response rates 85% and 67%, respectively). The patient groups were matched for parity, hormone replacement and diuretic therapy, and number of bladder operations and urinary tract infections, although OA patients were slightly older. RESULTS: AUA-7 urological symptoms were more severe in patients with primary SS compared to OA controls (p = 0.039). Severe urological symptoms were reported by 61% of primary SS patients compared with 40% of OA controls. This difference was predominantly attributable to bladder irritability associated with urgency (p = 0.015) and not nocturia (p = 0.85). Epworth Sleepiness Scale scores were also more severe in primary SS patients compared to OA controls (p = 0.02), independent of nocturia. The FACIT-F fatigue severity scores were not significantly different between patient groups (p = 0.14). CONCLUSION: Urological symptoms and daytime somnolence may be previously unrecognized symptoms of primary SS. These symptoms are consistent with functional disturbances of muscarinic receptors, possibly mediated by muscarinic receptor autoantibodies. |
Keywords: | Humans Sjogren's Syndrome Osteoarthritis Urologic Diseases Fatigue Ribonucleoproteins Autoantibodies Antibodies, Antinuclear Rheumatoid Factor Autoantigens Severity of Illness Index Case-Control Studies Cohort Studies Sleep Stages Circadian Rhythm Adult Aged Aged, 80 and over Middle Aged Female |
Rights: | Copyright © 2003 The Journal of Rheumatology |
Description (link): | http://www.jrheum.org.proxy.library.adelaide.edu.au/content/30/11/2406.abstract |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.