Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9937
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Type: Journal article
Title: Quantitative assessment of aortic sclerosis using ultrasonic backscatter
Author: Ngo, D.
Wuttke, R.
Turner, S.
Marwick, T.
Horowitz, J.
Citation: Journal of the American Society of Echocardiography, 2004; 17(11):1123-1130
Publisher: Mosby Inc
Issue Date: 2004
ISSN: 0894-7317
1097-6795
Statement of
Responsibility: 
Doan T. M. Ngo, Ronald D. Wuttke, Stuart Turner, Thomas H. Marwick, and John D. Horowitz
Abstract: Background: The development of therapeutic interventions to prevent progressive valve damage is more likely to limit the progression of structural damage to the aortic valve with normal function (aortic sclerosis [ASC]) than clinically apparent aortic stenosis. Currently, the ability to appreciate the progression of ASC is ompromised by the subjective and qualitative evaluation of sclerosis severity. Methods: We sought to reveal whether the intensity of ultrasonic backscatter could be used to quantify sclerosis severity in 26 patients with ASC and 23 healthy young adults. Images of the aortic valve were obtained in the parasternal long-axis view and saved in raw data format. Six square-shaped 11 × 11 pixel regions of interest were placed on the anterior and posterior leaflets, and calibrated backscatter values were obtained by subtracting the regions of interest in the blood pool from the averaged backscatter values obtained from the leaflets. Results: Mean ultrasonic backscatter values for sclerotic valves exceeded the results in normal valve tissue (16.3 ± 4.4 dB vs 9.8 ± 3.3 dB, P < .0001). Backscatter values were greater (22.0 ± 3.5 dB) in a group of 6 patients with aortic stenosis. Within the sclerosis group, the magnitude of backscatter was directly correlated (P < .05) with a subjective sclerosis score, and with transvalvular pressure gradient. Mean reproducibility was 2.4 ± 1.8 dB (SD) between observers, and 2.3 ± 1.7 dB (SD) between examinations. Conclusion: Measurement of backscatter from the valve leaflets of patients with ASC may be a feasible means of following the progression and treatment response of aortic sclerosis.
Keywords: Humans; Aortic Valve Stenosis; Echocardiography, Doppler; Severity of Illness Index; Statistics, Nonparametric; Case-Control Studies; Reproducibility of Results; Aged; Aged, 80 and over; Middle Aged; Female; Male
Rights: © Copyright 2004 by the American Society of Echocardiography.
RMID: 0020041051
DOI: 10.1016/j.echo.2004.06.012
Appears in Collections:Medicine publications

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