Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/99633
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Platelet hyperaggregability in patients with atrial fibrillation: Evidence of a background proinflammatory milieu |
Author: | Procter, N. Ball, J. Ngo, D. Chirkov, Y. Isenberg, J. Hylek, E. Stewart, S. Horowitz, J. |
Citation: | Herz: Cardiovascular Diseases, 2016; 41(1):57-62 |
Publisher: | Urban & Vogel |
Issue Date: | 2016 |
ISSN: | 0340-9937 1615-6692 |
Statement of Responsibility: | Nathan E.K. Procter, Jocasta Ball, Doan T.M. Ngo, Yuliy Y. Chirkov, Jeffrey S. Isenberg, Elaine M. Hylek, Simon Stewart, John D. Horowitz |
Abstract: | Objective: Atrial fibrillation (AF) is a condition where platelet hyperaggregability is commonly present. We examined potential physiological bases for platelet hyperaggregability in a cohort of patients with acute and chronic AF. In particular, we sought to identify the impact of inflammation [myeloperoxidase (MPO) and C-reactive protein (CRP)] and impaired nitric oxide (NO) signaling. Methods: Clinical and biochemical determinants of adenosine diphosphate (ADP)-induced platelet aggregation were sought in patients (n = 106) hospitalized with AF via univariate and multivariate analysis. Results: Hyper-responsiveness of platelets to ADP was directly (r = 0.254, p < 0.01) correlated with plasma concentrations of thrombospondin-1 (TSP-1), a matricellular protein that impairs NO responses and contributes to development of oxidative stress. In turn, plasma TSP-1 concentrations were directly correlated with MPO concentrations (r = 0.221, p < 0.05), while MPO concentrations correlated with those of asymmetric dimethylarginine (ADMA, r = 0.220, p < 0.05), and its structural isomer symmetric dimethylarginine (SDMA, r = 0.192, p = 0.05). Multivariate analysis identified TSP-1 (β = 0.276, p < 0.05) concentrations, as well as female sex (β = 0.199, p < 0.05), as direct correlates of platelet aggregability, and SDMA concentrations (β = − 0.292, p < 0.05) as an inverse correlate. Conclusion: We conclude that platelet hyperaggregability, where present in the context of AF, may be engendered by impaired availability of NO, as well as via MPO-related inflammatory activation. |
Keywords: | Atrial fibrillation thrombospondin-1 myeloperoxidase asymmetric dimethylarginine platelet aggregation |
Rights: | © Urban & Vogel 2015 |
DOI: | 10.1007/s00059-015-4335-y |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1007/s00059-015-4335-y |
Appears in Collections: | Aurora harvest 7 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.