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https://hdl.handle.net/2440/99961
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Type: | Journal article |
Title: | Inflammation and neurodegenerative disorders: is there still hope for therapeutic intervention? |
Author: | Baune, B. |
Citation: | Current Opinion in Psychiatry, 2015; 28(2):148-154 |
Publisher: | Lippincott Williams and Wilkins |
Issue Date: | 2015 |
ISSN: | 0951-7367 1473-6578 |
Statement of Responsibility: | Bernhard T. Baune |
Abstract: | Purpose of review: This review aims to describe the current understanding of neuroinflammation in neurodegeneration and evaluate the value of various anti-inflammatory treatments. Recent findings: Inflammation plays important roles in common disease such as dementia and depression. Underlying mechanisms including the role of inflammasomes in these diseases have been recently described. Interventions using [OMEGA]-3 polyunsaturated fatty acids, NSAIDs and targeted antagonists (e.g., etanercept) show no convincing clinical efficacy in inflammation-associated depression, cognitive decline and dementia. Summary: Therapeutic targeting of inflammation appears to be relevant in brain conditions characterized by neuroinflammation and neurodegeneration, although published anti-inflammatory interventions have shown no relevant clinical efficacy. Newly described pharmacological targets in the neuroinflammation pathways may not only offer a more profound understanding of the underlying pathophysiology but also raise hope for the development of novel pharmacological agents. |
Keywords: | Anti-inflammation; immune modulation ; inflammation; intervention; neurodegeneration |
Rights: | Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. |
DOI: | 10.1097/YCO.0000000000000140 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1060524 |
Published version: | http://dx.doi.org/10.1097/yco.0000000000000140 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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