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https://hdl.handle.net/2440/112258
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Type: | Journal article |
Title: | Investigation of short tandem repeats in major depression using whole-genome sequencing data |
Author: | Yu, C. Baune, B. Wong, M. Licinio, J. |
Citation: | Journal of Affective Disorders, 2018; 232:305-309 |
Publisher: | Elsevier BV |
Issue Date: | 2018 |
ISSN: | 0165-0327 1573-2517 |
Statement of Responsibility: | Chenglong Yu, Bernhard T. Baune, Ma-Li Wong, Julio Licinio |
Abstract: | Background: Major depressive disorder (MDD) is a leading contributor to global disease burden. Recent studies have shown that genetic factors play significant roles in the susceptibility to this condition; however, the underlying genetic basis currently remains largely unknown. Short tandem repeat (STR) has been proposed as an explanatory factor in the “missing heritability” of complex diseases or traits. Methods: We investigated STR variations from 15 MDD patients and 10 ethnically matched healthy controls based on their deep whole-genome sequencing (WGS) data. The lobSTR software was used to computationally determine STRs. Results: The results of the Mexican-American sample showed that STRs are significantly richer in healthy controls than in MDD cases on each of the 23 chromosomes (all false discovery rates, FDR P-values< 0.0062); while for the Australian of European-ancestry sample, there was no statistically significant STRs difference between MDD cases and controls. Limitations: High quality WGS costs limited obtaining larger datasets. Conclusions: This preliminary work is the first study that STR variations are applied to investigate MDD based on WGS data. The results on Mexican-American population may imply that within the same ancestry, targeted sequencing on a specific chromosome or region of genome would be sufficient for examining the relationship between STR and MDD. Further studies should examine larger sequencing datasets on other ethnic groups. |
Keywords: | Major depressive disorder Heritability Psychiatric genetics Whole-genome sequencing Genetic marker |
Description: | Available online 24 February 2018 |
Rights: | © 2018 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.jad.2018.02.046 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1051931 http://purl.org/au-research/grants/nhmrc/1060524 |
Published version: | http://dx.doi.org/10.1016/j.jad.2018.02.046 |
Appears in Collections: | Aurora harvest 3 Psychiatry publications |
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