Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/133198
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Type: | Journal article |
Title: | The influence of Prenatal DHA supplementation on individual domains of behavioral functioning in school‐aged children: Follow‐up of a randomized controlled trial |
Author: | Gould, J.F. Anderson, P.J. Yelland, L.N. Gibson, R.A. Makrides, M. |
Citation: | Nutrients, 2021; 13(9):2996-1-2996-20 |
Publisher: | MDPI |
Issue Date: | 2021 |
ISSN: | 2072-6643 2072-6643 |
Statement of Responsibility: | Jacqueline F. Gould, Peter J. Anderson, Lisa N. Yelland, Robert A. Gibson, and Maria Makrides |
Abstract: | Docosahexaenoic acid (DHA) accumulates in the fetal brain during pregnancy and is thought to have a role in supporting neurodevelopment. We conducted a multicenter, double-blind, randomized controlled trial in women with a singleton pregnancy who were <21 weeks’ gestation at trial entry. Women were provided with 800 mg DHA/day or a placebo supplement from trial entry until birth. When children reached seven years of age, we invited parents to complete the Strengths and Difficulties Questionnaire (SDQ), the Behavior Rating Inventory of Executive Function (BRIEF), and the Conners 3rd Edition Attention-Deficit Hyperactivity Disorder (ADHD) Index to assess child behavior and behavioral manifestations of executive dysfunction. There were 543 parent–child pairs (85% of those eligible) that participated in the follow-up. Scores were worse in the DHA group than the placebo group for the BRIEF Global Executive, Behavioral Regulation and Metacognition Indexes, and the Shift, Inhibit, Monitor, Working Memory, and Organization of Materials scales, as well as for the Conners 3 ADHD index, and the SDQ Total Difficulties score, Hyperactivity/Inattention score, and Peer Relationship Problems score. In this healthy, largely term-born sample of children, prenatal DHA supplementation conferred no advantage to childhood behavior, and instead appeared to have an adverse effect on behavioral functioning, as assessed by standardized parental report scales. |
Keywords: | DHA; RCT; omega-3 fatty acids; supplementation; behavior; behavioral problems; prenatal |
Rights: | Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
DOI: | 10.3390/nu13092996 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/349301 http://purl.org/au-research/grants/nhmrc/1048493 http://purl.org/au-research/grants/nhmrc/1061704 http://purl.org/au-research/grants/nhmrc/1052388 http://purl.org/au-research/grants/nhmrc/1176077 |
Published version: | http://dx.doi.org/10.3390/nu13092996 |
Appears in Collections: | Psychology publications |
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