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|Title:||Cytotoxin with a subtilase domain|
|Contributor:||Coleman, Henry D.|
Sudol, R. Neil
Sapone, William J.
|Inventors A. W. Paton, J. C. Paton; Assigned to Adelaide Research and Innovation Pty Ltd; R. N. Sudol, H. D. Coleman and W. J. Sapone agents to inventors.|
|Abstract:||A member of a new class of bacterial toxin has been isolated and characterised. The bacterial toxin is of the AB₅ type and is characterised in that it has a subtilase domain. It is cytotoxic to Vero cells, and toxicity in vivo in mice occurs in a number of different sites. Mutation of the serine active residue results in greater than 99% reduction in activity. The protein has been purified and antibodies have been prepared for both the A subunit and B subunits, and ELISA detection methods have been developed. The nucleic acid sequence has been determined and primers specific for the toxin have been used for a preliminary screen of a range of patient samples to ascertain the extent to which the toxin is present.|
|Description:||PATENT: A. W. Paton, J. C. Paton (Assignee Adelaide Research and Innovation Pty Ltd). US 7078489 filed May 12, 2004; published Jul 18, 2006; granted until May 12, 2024.|
|Appears in Collections:||Molecular and Biomedical Science publications|
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