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Type: Journal article
Title: Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery
Author: Shi, B.
Zhang, H.
Dai, S.
Du, X.
Bi, J.
Qiao, S.
Citation: Small, 2014; 10(5):871-877
Publisher: Wiley - VCH Verlag GmbH & Co KGaA
Issue Date: 2014
ISSN: 1613-6810
Statement of
Bingyang Shi, Hu Zhang, Sheng Dai, Xin Du, Jingxiu Bi and Shi Zhang Qiao
Abstract: A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency.
Keywords: Hela Cells; Humans; Schiff Bases; Imidazoles; Polymers; Chitosan; DNA; Gene Transfer Techniques; Transfection; Plasmids; Particle Size; Cellular Microenvironment
Rights: © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
RMID: 0020136431
DOI: 10.1002/smll.201302430
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Appears in Collections:Chemical Engineering publications

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