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|Scopus||Web of Science®||Altmetric|
|Title:||Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery|
|Citation:||Small, 2014; 10(5):871-877|
|Publisher:||Wiley - VCH Verlag GmbH & Co KGaA|
|Bingyang Shi, Hu Zhang, Sheng Dai, Xin Du, Jingxiu Bi and Shi Zhang Qiao|
|Abstract:||A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency.|
|Keywords:||Hela Cells; Humans; Schiff Bases; Imidazoles; Polymers; Chitosan; DNA; Gene Transfer Techniques; Transfection; Plasmids; Particle Size; Cellular Microenvironment|
|Rights:||© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim|
|Appears in Collections:||Chemical Engineering publications|
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