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|Title:||Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects|
|Citation:||Gut, 1997; 41(4):494-499|
|Publisher:||BRITISH MED JOURNAL PUBL GROUP|
|A Russo, W M Sun, Y Sattawatthamrong, R Fraser, M Horowitz, J M Andrews, N W Read|
|Abstract:||BACKGROUND:The pathogenesis of anorectal dysfunction, which occurs frequently in patients with diabetes mellitus, is poorly defined. Recent studies indicate that changes in the blood glucose concentration have a major reversible effect on gastrointestinal motor function. AIMS:To determine the effects of physiological changes in blood glucose and hyperglycaemia on anorectal motor and sensory function in normal subjects. SUBJECTS:In eight normal subjects measurements of anorectal motility and sensation were performed on separate days while blood glucose concentrations were stabilised at 4, 8, and 12 mmol/l. METHODS:Anorectal motor and sensory function was measured using a sleeve/sidehole catheter incorporating a balloon, and electromyography. RESULTS:The number of spontaneous anal relaxations was greater at 12 mmol/l than at 8 and 4 mmol/l glucose (p < 0.05 for both). Anal squeeze pressures were less at a blood glucose of 12 mmol/l when compared with 8 and 4 mmol/l (p < 0.05 for both). During rectal distension, residual anal pressures were not significantly different between the three blood glucose concentrations. Rectal compliance was greater (p < 0.05) at a blood glucose of 12 mmol/l when compared with 4 mmol/l. The threshold volume for initial perception of rectal distension was less at 12 mmol/l when compared with 4 mmol/l (40 (20-100) ml versus 10 (10-150) ml, p < 0.05). CONCLUSIONS:An acute elevation of blood glucose to 12 mmol/l inhibits internal and external anal sphincter function and increases rectal sensitivity in normal subjects. In contrast, physiological changes in blood glucose do not have a significant effect on anorectal motor and sensory function.|
|Keywords:||Rectum; Humans; Hyperglycemia; Acute Disease; Glucose Clamp Technique; Analysis of Variance; Statistics, Nonparametric; Single-Blind Method; Manometry; Sensory Thresholds; Gastrointestinal Motility; Adolescent; Adult; Middle Aged; Anal Canal; Male|
|Appears in Collections:||Medicine publications|
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