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Type: Journal article
Title: Measurement of gastric emptying by intragastric gamma scintigraphy
Author: Malbert, C.
Mathis, C.
Bobillier, E.
Laplace, J.
Horowitz, M.
Citation: Neurogastroenterology and Motility, 1997; 9(3):157-165
Issue Date: 1997
ISSN: 1350-1925
Statement of
C. H. Malbert, C. Mathis, E. Bobillier, J. P. Laplace, M. Horowitz
Abstract: Gastric emptying is usually measured in animals and humans by dilution/sampling or external scintigraphy. These methods are either time consuming or require expensive equipment. The capacity of a miniature gamma counter positioned in the stomach to measure emptying of liquid and solid meals was evaluated. In eight conscious pigs fitted with gastric and duodenal cannulae, gastric emptying of saline (500 mL), dextrose (20%, 500 mL), porridge (300 g) and scrambled eggs (300 g), all labelled with 3.5 MBq 99mTC, was evaluated. When positioned in the antrum the probe was unable to quantify gastric emptying. In contrast, measurements of the fractional emptying of saline over 4-min periods by the probe positioned in the corpus and quantification of radioactivity in the duodenal effluent correlated closely (r = 0.88, P < 0.05). Gastric emptying (50% emptying time) of saline and both solid meals measured by the probe was not significantly different from quantification of the duodenal effluent volume. No difference was observed also for the dextrose meal but only while gastric acid secretion was suppressed by omeprazole. We conclude that an intragastric gamma counter permits measurement of gastric emptying of homogeneous meals provided meal stimulation of gastric secretion was not extensive. This was possible probably by monitoring emptying from the proximal stomach.
Keywords: Duodenum; Stomach; Animals; Swine; Cadmium; Radionuclide Imaging; Scintillation Counting; Gastric Emptying; Pressure
RMID: 0030004793
DOI: 10.1046/j.1365-2982.1997.d01-38.x
Appears in Collections:Medicine publications

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